Fig. 5. Comparison of (A ) halothane versus  (B ) sevoflurane interactions with BayK8644-induced elevation of Ca²⁺influx. When sarcoplasmic reticulum (SR) and Na⁺–Ca²⁺exchange (NCX) were inhibited by ryanodine, thapsigargin (TG), and KBR 7943, the increase in Ca²⁺influx by BayK8644 was considerably greater in neonates. Subsequent exposure to anesthetic decreased influx to a greater extent in neonates. *Difference from previous condition; §age-related difference; †difference between 1 and 2 minimum alveolar concentration (MAC); ‡difference between halothane and sevoflurane. Values are mean ± SD.