Fig. 11. Age-related differences in the effect of volatile anesthetics on the Na⁺-dependence of Na⁺–Ca²⁺exchange (NCX)-mediated efflux. The rate of Ca²⁺efflux was determined after reactivating efflux with one of three different extracellular Na⁺concentrations. Both anesthetics blunted the relation between Na⁺concentration and Ca²⁺efflux rate in neonates (A  and C ) as well as adults (B  and D ), with the effect being greater in neonates. *Difference from control; §age-related differences; ‡difference between halothane and sevoflurane. Values are mean ± SD.