Fig. 6. (A ) Schematic drawing of skin incision (arrow) and a strip of skin anesthetized by lidocaine (dotted line). (B ) Time courses of experimental incision-evoked pain and subsequent spontaneous pain determined by the visual analog scale (VAS) in trials of pretraumatic (open circles) and posttraumatic (filled circles) injection of lidocaine. (C ) Time courses of mechanical (von Frey hair) pain thresholds to punctate stimuli in trials of pretraumatic injection of lidocaine in a strip of skin. (D ) Time courses of mechanical (von Frey hair) pain thresholds to punctate stimuli in trials of posttraumatic injection of lidocaine in a strip of skin. *P < 0.01 versus prevalue. Data are shown as mean ± SEM in (B ). The box and whisker plots in (C ) and (D ) are described in Fig. 3.