Fig. 1. Changes in local cerebral blood flow (LCBF) measured by a laser Doppler flowmeter during ischemia and reperfusion in the vehicle and lidocaine groups. Flow values shown are averages of measurements made during 30-s periods every 10 min and expressed as percent of baseline before ischemia (mean ± SD, n = 7 for each group). The first ischemic point is the value at 2 min after the onset of ischemia. The lidocaine group was not significantly different from the vehicle group at any time point.