![Fig. 6. Effects of cyclopropane (5 minimum alveolar concentration [MAC]) on GABAAα2subunit mutants receptors coexpressed with β1subunit. Serine at position 270 in the α2subunit was substituted with amino acid with increasing volume of the side chain, i.e. , threonine (S270T), asparagine (S270N), isoleucine (S270I), tyrosine (S270Y), and tryptophan (S270W). Except α2(S270W)β1receptor, none of the mutant receptors showed any significant difference from the α2β1wild-type receptors. Error bars represent SEM; n = 4–10 oocytes.](https://asa2.silverchair-cdn.com/asa2/content_public/journal/anesthesiology/97/6/10.1097_00000542-200212000-00025/2/25ff6.png?Expires=1716562543&Signature=zWGKkRwyeUBkZXw73LiunGF6xCciSNS9bqMJD~4s9~i6VkW5R7cOa2YrenS7Xp-emSlVEaAC-1hifdrF4Z0Aei74jeEXMnSFtzYZeoSGaRAnJgDS~FOKD9WARQmlUrDPfmoxJPaK4bV34~2t-39OiiIjbpQBPpARlvzByBrAml3MFRIbjrE9D5BL3hIIGo7e5tTkFnFoAepGABnDoFJAMp57mdeb0X4WjsZZc92qwW3FVIEGKNYO-RmhV226jNcCyRCHmc2uyX5RlWFLurx2WdFyY9Ayiqddy-OwdMFzvI3JfnJb7ZDdqrn5XmsrabXwUaM7EUpkWmZkvOK0KEBJ4A__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Fig. 6. Effects of cyclopropane (5 minimum alveolar concentration [MAC]) on GABAAα2subunit mutants receptors coexpressed with β1subunit. Serine at position 270 in the α2subunit was substituted with amino acid with increasing volume of the side chain, i.e. , threonine (S270T), asparagine (S270N), isoleucine (S270I), tyrosine (S270Y), and tryptophan (S270W). Except α2(S270W)β1receptor, none of the mutant receptors showed any significant difference from the α2β1wild-type receptors. Error bars represent SEM; n = 4–10 oocytes.
