Fig. 9. Simulation of a typical dosing regimen for remifentanil (1-μg/kg bolus, 0.4 μg · kg⁻¹· min⁻¹for 2.5 min, 0.2 μg · kg⁻¹· min⁻¹for the remaining period of administration [60 min]) in the presence and absence of propofol. Note the (expected) big difference of peak concentrations after the initial bolus, the small concentration difference during maintenance, and the negligible difference during recovery.