Fig. 3. Effect of chronic blockade of nNOS with 7-NI (2 × 40 mg/kg, intraperitoneal) on hyperemic response to isoflurane before and after administration of indomethacin (INDO, 10 mg/kg, intravenous) or N-methylsulfonyl-6-(2-proparglyoxyphenyl)hexanoic acid (PPOH). Data are expressed as mean ± SD; n = 5–6 animals. *Significantly (P < 0.05) different from 0.0 or 1.2 vol% isoflurane. †Significantly (P < 0.05) different from 1.8 vol% isoflurane. ‡Significantly (P < 0.05) different from control.