![Fig. 6. Summarized data for the effects of bisindolylmaleimide I (BIS) on propofol-induced changes in tension and [Ca2+]i(340/380 ratio) in ionomycin-pretreated pulmonary artery smooth muscle (PASM) strips. Propofol increased tension in a dose-dependent manner with a slight concomitant decrease in [Ca2+]i(*P < 0.05 vs. baseline). Pretreatment with BIS attenuated the propofol-induced increases in tension and decreases in [Ca2+]i(†P < 0.05 vs. control). Results are expressed as percentage changes relative to response to 60 mm KCl. n = 6, each.](https://asa2.silverchair-cdn.com/asa2/content_public/journal/anesthesiology/97/6/10.1097_00000542-200212000-00031/2/31ff6.png?Expires=1716506375&Signature=uLQogUetlFTIuZv3oabeZ2KudgVqQAN3MWepRfL4e5CN~KeoUcpwwbb6J2vXBat0exXvYZRJuSUqYRzP-PYDmkbx2SELxL5WlPjje-z-d26auFZGAzsYkh6pQ0wQIqAfl0BnKPEAkdotnMP7lQ0sGzyTksQ14RiV3-mEZRMxqu8L6bhuqyXiEGfyG7u~QSvWLdkbGc93Q8Qmo6QL4vKYCmE5WfQNVDjId0fi85FC0IVkRAUvsODcxRla3eKYnL02ovVSSn-9mvY7nFujLy4LKDguBwxBRKh0Q8DIxBf1wshojyDUH~bNOvZclKXoka7DNebSqFTrd39Vnqz0TIBMXw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Fig. 6. Summarized data for the effects of bisindolylmaleimide I (BIS) on propofol-induced changes in tension and [Ca2+]i(340/380 ratio) in ionomycin-pretreated pulmonary artery smooth muscle (PASM) strips. Propofol increased tension in a dose-dependent manner with a slight concomitant decrease in [Ca2+]i(*P < 0.05 vs. baseline). Pretreatment with BIS attenuated the propofol-induced increases in tension and decreases in [Ca2+]i(†P < 0.05 vs. control). Results are expressed as percentage changes relative to response to 60 mm KCl. n = 6, each.
