![Fig. 1. Effects of 30-min incubation in antidepressants on lysophosphatidic acid (LPA) signaling and membrane integrity in Xenopus oocytes. (A ) Example trace of LPA (10−4m)–induced peak Cl current under control conditions (left ) and after a 30-min incubation in nortriptyline at 10−4m (right ). Effects of a 30-min preincubation in (B ) nortriptyline (10−7–10−4m) or amitriptyline (10−7–10−3m) or (C ) imipramine (10−7–10−3m) or fluoxetine (10−7–10−4m) on LPA (10−4m)–stimulated Ca-activated peak Cl current (percentage of control response [bottom ]) and loss of cell integrity (holding current, > 1 μA; expressed as percentage above incidence in control cells [top ]). #Not determined. Data are mean ± SD. *P < 0.05 versus control.](https://asa2.silverchair-cdn.com/asa2/content_public/journal/anesthesiology/99/4/10.1097_00000542-200310000-00025/2/25ff1.png?Expires=1716485524&Signature=MHdqTXxf3pGOVGyTOFehqG2BaCZZGkWz~M-Kjq6DrYj~je8ZHaZMDZR~pGQzgO5wUw6jaQ1aDD11KYtVSZn0M1NXCESK73PUtsUXmXxX-T87QZNaPacpBKlZe7GU1az-Yn9QyMmv0i-wUj02FRWZOtdJRpMXhSU-M0a6O~0ZOYB4p-342OrdhG8uq8XQ8qwXjuW8ltJAkquG5Q-Ac9KsOZH9-I~V-5yzPqttNotUwNCftBYglL4M5VArRvU3R~sFyayNB8TTHn~ZGfDXByynKGl8gN9ngTLMJmCk2QzaPMIgNw7rXagl6vwJxq4KvQsfOhvg5slRJiZOEAQilcKcNw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Fig. 1. Effects of 30-min incubation in antidepressants on lysophosphatidic acid (LPA) signaling and membrane integrity in Xenopus oocytes. (A ) Example trace of LPA (10−4m)–induced peak Cl current under control conditions (left ) and after a 30-min incubation in nortriptyline at 10−4m (right ). Effects of a 30-min preincubation in (B ) nortriptyline (10−7–10−4m) or amitriptyline (10−7–10−3m) or (C ) imipramine (10−7–10−3m) or fluoxetine (10−7–10−4m) on LPA (10−4m)–stimulated Ca-activated peak Cl current (percentage of control response [bottom ]) and loss of cell integrity (holding current, > 1 μA; expressed as percentage above incidence in control cells [top ]). #Not determined. Data are mean ± SD. *P < 0.05 versus control.
