![Fig. 2. Effects of a 120-min incubation in antidepressants on lysophosphatidic acid (LPA) signaling and membrane integrity in Xenopus oocytes. Effects of a 120-min preincubation in (A ) nortriptyline (10−7–10−4m) or amitriptyline (10−7–10−3m) or (B ) imipramine (10−6–10−3m) or fluoxetine (10−7–10−4m) on LPA (10−4m)–stimulated Ca-activated peak Cl current (percentage of control response [top ]) and loss of cell integrity (holding current, > 1 μA; expressed as percentage above incidence in control cells [bottom ]). #Not determined. Data are mean ± SD. *P < 0.05 versus control.](https://asa2.silverchair-cdn.com/asa2/content_public/journal/anesthesiology/99/4/10.1097_00000542-200310000-00025/2/25ff2.png?Expires=1716915953&Signature=gsHem2Ui-2W4vlb4mb2hrGJIJ4SV2bIvyr3L9Svmux4r3AxJByXLLG0AwTSZ9UPU3ik-GoP5uES0Kf8T-ubyVfobC3zZ-DW-awIJiYWm1D72hKqCwhcmOINefbshdDaeBzLglf-zdPH74ywlvow2SgoAD9D-FsVn9tPv0A~vODdqAM1-DADzUr~7xrUVBbNyBxKoGjx4lgoTkMi65VmEmRRScuJIyhr-EYI7NIn7h8HM6DJVzcLYCu2NVrTAZ7KqPZBr2N5zXISSsqgRmKlxJtp6pmA1DplnxT36yz-zeGMB59EyPaPXW4HpZPi6dZDj3U3MP7ARgS9ewr-73peYQA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Fig. 2. Effects of a 120-min incubation in antidepressants on lysophosphatidic acid (LPA) signaling and membrane integrity in Xenopus oocytes. Effects of a 120-min preincubation in (A ) nortriptyline (10−7–10−4m) or amitriptyline (10−7–10−3m) or (B ) imipramine (10−6–10−3m) or fluoxetine (10−7–10−4m) on LPA (10−4m)–stimulated Ca-activated peak Cl current (percentage of control response [top ]) and loss of cell integrity (holding current, > 1 μA; expressed as percentage above incidence in control cells [bottom ]). #Not determined. Data are mean ± SD. *P < 0.05 versus control.
