Fig. 1. Changes in Bispectral Index (BIS), infusion rate of propofol, mean arterial pressure, cardiac output, and flow rate of a partial cardiopulmonary bypass of distal perfusion before, during, and after aortic cross-clamp. CO = cardiac output measured by Swan-Ganz catheter; Cp = plasma concentrations of propofol measured by high-performance liquid chromatography; CPB = partial cardiopulmonary bypass for distal perfusion; MAP = mean arterial pressure in the right radial artery.