Fig. 3. Reversal by peripheral (intrapaw) AM1241 of carrageenan-induced hind paw edema. Antagonism of the effects of AM1241 by the CB²receptor–selective antagonist AM630 (100 μg/kg), but not by the CB¹receptor–selective antagonist AM251 (300 μg/kg). Data are expressed as mean ± SEM. Groups were compared using ANOVA followed by pair-wise comparisons using the Student t  test with Bonferroni correction. *P < 0.05 compared with precarrageenan baseline; #P < 0.05 compared with postcarrageenan value; +P < 0.05 compared with AM1241 alone; n = 6 per group. BL = precarrageenan baseline; CG = postcarageenan value.