Fig. 1. Hypnotic effects of etomidate and thiopental in wild-type (WT), α^2A-receptor–deficient (α^2A-KO), and α^2B-receptor–deficient (α^2B-KO) mice. Etomidate (30 mg/kg) or thiopental (50 mg/kg) were intraperitoneally injected into male mice (n = 5 per genotype) and the time until loss of righting reflex (LRR) and recovery of the reflex (RRR) were monitored. Deletion of the α^2A- or α^2B-receptor genes did not influence the hypnotic effects of etomidate or thiopental.