Fig. 1. Schematic illustration of the experimental protocol used during myocardial infarct size experiments. Celecoxib (CEL; 3 mg/kg intraperitoneal) was administered five times over 2 days at 48, 36, 24.5, 12, and 2.5 h before left anterior descending coronary artery occlusion. CON = control; ISO = isoflurane; M = administration of a single dose of celecoxib during the mediator phase (2.5 h before left anterior descending coronary artery occlusion); MAC = minimum alveolar concentration; T = administration of a single dose celecoxib during the trigger phase (30 min before exposure to isoflurane).