Fig. 3. Ketamine inhibition of α7 nicotinic receptor. The IC50for ketamine inhibition of the α7 nicotinic mutant A258S was 30 ± 3 μm ketamine (Hill coefficient, 1.3 ± 0.2). The ketamine inhibitory response of the wild-type (•) and mutant (□) α7 nicotinic receptors was significantly different (ANOVA; P < 0.001). Number of oocytes for each data point = 4–11. Values are mean ± SE.