Fig. 3. In the presence of tetrodotoxin (1 μm), propofol at concentrations of 1 μm and greater significantly increased the decay time of γ-aminobutyric acid (GABA)–mediated miniature inhibitory postsynaptic currents (mIPSCs) in parasympathetic cardiac vagal neurons. Representative traces of GABA-mediated mIPSCs are shown in the top portion , at propofol concentrations of 0.1, 1.0, 5.0, 10.0, 50.0, and 100 μm. The average results from eight cardiac vagal neurons are shown in the bottom portion . *P < 0.05, **P < 0.01.

Fig. 3. In the presence of tetrodotoxin (1 μm), propofol at concentrations of 1 μm and greater significantly increased the decay time of γ-aminobutyric acid (GABA)–mediated miniature inhibitory postsynaptic currents (mIPSCs) in parasympathetic cardiac vagal neurons. Representative traces of GABA-mediated mIPSCs are shown in the top portion , at propofol concentrations of 0.1, 1.0, 5.0, 10.0, 50.0, and 100 μm. The average results from eight cardiac vagal neurons are shown in the bottom portion . *P < 0.05, **P < 0.01.

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