Fig. 2. Analgesic response to individual drugs. Tail-flick latency was assessed 30 min after (A ) placing animals in a chamber containing a specified concentration of nitrous oxide (N2O) (mean ± SEM; n = 5), (B ) intraperitoneal (i.p.) dexmedetomidine was administered (n = 4–8), or (C ) intrathecal (i.t.) dexmedetomidine was administered in 10 μl saline (n = 4–8), as described in the Materials and Methods. MPE = maximal possible effect.
