Fig. 4. During a brief anesthetic period, etomidate produced less hypothermia in γ-aminobutyric acid type A (GABAA) receptor β2N265S mice compared with wild-type (WT) mice. After a brief anesthetic period induced by a 5-mg/kg single intravenous bolus, GABAAreceptor β2N265S mice (open triangles ) showed a smaller CBT reduction (genotype: F1,6= 95.5, P < 0.0001) for a shorter time (genotype × time interaction: F90,540= 67.5, P < 0.0001) than WT controls (filled squares ). Time to recover normothermia was faster in GABAAreceptor β2N265S mice compared with WT controls. Error bars =± SEM. Left dotted line indicates mean time of recovery of righting reflex in WT mice; right dotted line indicates mean time of recovery in GABAAreceptor β2N265S mice. n = 4 for each genotype.