Fig. 6. Effects of protein kinase C inhibitors on anesthetic-induced increase in tyrosine phosphorylation in rat hippocampal slices. Data (mean ± SD) are expressed as a fractional increase from basal phosphorylation (control = 100%). The anesthetics and pharmacologic agents were used at the following concentrations: desflurane, sevoflurane, and isoflurane: 0.3 mm; propofol, etomidate, and thiopental: 5 μm; GF 109203X, RO 318220, and chelerythrin: 100 μm. **  P < 0.01 and ***  P < 0.001  versus control. #  P < 0.05 and ##  P < 0.01  versus anesthetic-induced tyrosine phosphorylation.