Fig. 1. Concentration–response curves to levcromakalim (10−8to 10−5m) in the absence and in the presence of glibenclamide (10−5m), obtained in the rat thoracic aorta with or without endothelium. Data are shown as mean ± sd and expressed as percent of maximal vasorelaxation induced by papaverine (3 × 10−4m). * Difference between control rings and rings treated with glibenclamide is statistically significant ( P < 0.05).