Fig. 5. Mean area under the curve (mAUC) for inadequate bispectral index values from 5 min after control start until beginning of skin closure. A bispectral index value above 60 or less than 40 was considered as inadequate. Each bar represents one patient experiment, sorted by mAUC of bispectral index >60. The area was defined by the curve above 60 or less than 40 respectively and was scaled with the total observation time.