Fig. 1. Kaplan-Meier survival curves were generated for C57 mice subjected to cecal ligation and double puncture with saline infusion (n = 35), C57 mice subjected to cecal ligation and double puncture while receiving infusion of 5% (n = 20) or 10% (n = 35) lidocaine, and C57 mice subjected to cecal ligation and double puncture treated with infusion of 1% (n = 27) or 2% (n = 21) bupivacaine. Log-rank analysis demonstrated a significant improvement in survival for all local anesthetic infusion groups versus the saline vehicle group ( P < 0.05). Log-rank analysis also demonstrated a significant improvement in survival in the 2% bupivacaine infusion group versus the 1% bupivacaine infusion group ( P < 0.05). No statistical differences in mortality were observed between the lidocaine infusion groups. BUPIV = bupivacaine; LIDO = lidocaine .