Fig. 4. Representative tracings of the effects of the anesthetics ( A ) propofol (1 × 10−6∼ 3 × 10−5M) and ( B ) sevoflurane (0.5∼2.0%) on spontaneously activity in isolated lymph vessel segments without endothelial function. Even without endothelial function, isolated vessels exhibited stretch-induced spontaneous contraction. As was found in the experiment with intact endothelial function, both anesthetics caused dose-dependent inhibition of spontaneous lymphatic activity (amplitude). Both of the anesthetics also caused dose-dependent inhibition of the frequency of spontaneous lymphatic activity.
