Fig. 5. Time courses of responses to mechanical stimuli ( A ) and receptive field (RF) sizes of wide-dynamic-range (WDR) neurons ( B ). Results are shown for the WDR neurons (n = 13) in which recordings were successfully performed for more than 4 h after the incision had been made. The responses to nonnoxious and noxious stimuli greatly increased immediately after the incision had been made, and the increased responses were sustained for a long duration. The RF sizes greatly increased immediately after the incision had been made, but the RF sizes gradually decreased from 4 h after the incision had been made. BR, brush stimulation; VF, stimulation using a 4-g von Frey hair; PP, pinprick stimulation using a 16-g tungsten tip; PI, pinch stimulation using an arterial clip with a force of 250 g/mm2.