Fig. 3. Individual data fits of all eight subjects receiving morphine: respiration at a fixed end-tidal partial pressure of carbon dioxide (  left column ), the acute hypoxic response (AHR,  middle column ), and pain tolerance (  right column ).  Dotted lines are the measured data, and the  continuous lines are the model (Bayesian) prediction. (A) Subjects 4, 10, 34, and 38 received morphine at 9:00 am; (B) subjects 36, 45, 51, and 55 received morphine at 6:00 pm. Subjects 4 and 34 received 0.13 mg/kg, and the others received 0.2 mg/kg.