Fig. 6. Effects of bicuculline, strychnine, or both agents on spontaneous action potential firing of spinal neurons. Bicuculline (100 μm) or strychnine (1 μm) or a combination of both antagonists accelerated the mean firing rate (action potential firing rate), whereas they depressed the burst rate ( t test, * P < 0.05, ** P < 0.01, *** P < 0.001).