Fig. 1. Simulation of 1,000 patients receiving either a 10-mg bolus of propofol (  top graph ), a propofol infusion at 10 mg/minT1-5016 (  middle graph ), or a target-controlled infusion of propofol at a target plasma concentration of 1 μg/ml (  bottom graph ). The log scale permits visual assessment of the coefficient of variation for the three drug delivery paradigms. The coefficient of variation is greater with bolus injection.