Fig. 1. (  A ) Time course of state entropy (SE), response entropy (RE), Bispectral Index (BIS), and burst suppression ratio (BSR) of patient 1. Each symbol represents an electroencephalographic parameter of a 5-s epoch. (  B ) End-tidal sevoflurane concentration (C^et) and calculated effect site concentration (C^eff) during the same time course in the same patient.