Fig. 5. Effects of ketamine racemate on sulfonylurea receptor (SUR) chimeras. ( A ) Schematic representation of wild-type and chimeric SURs. Open regions indicate SUR1 and solid regions indicate SUR2A. ( B ) Effects of ketamine racemate (1 mm) on single-channel currents of reconstituted inwardly rectifying potassium channel (Kir) 6.2 with SUR1, SUR2A, chimera SUR1–2, and chimera SUR2–1. The dotted lines indicate the mean inhibition of SUR1/Kir6.2 and SUR2A/Kir6.2 currents. The numbers in brackets indicate the number of patches. For statistical analysis, the chimeras based on SUR1 ([squlf]) were compared with SUR1, and the chimeras based on SUR2A (▪) were compared with SUR2A. * P < 0.05 .