Fig. 5. Concentration–response curves to levcromakalim in the absence or in the presence of phorbol 12-myristate 13-acetate (PMA, 3 × 10−6m) in combination with calphostin C (3 × 10−7m) or Gö 6976 (3 × 10−7m), obtained in the porcine coronary artery without endothelium. * Differences between rings treated with PMA and control rings or rings treated with PMA in combination with calphostin C or Gö 6976 are statistically significant ( P < 0.05).