Fig. 3. Examples of model fits of the analgesic data from  OPRM1:c.118AA (  white circles ) and model fits of all of the  OPRM1:c.118GA subjects (  black circles ). The data presented with  white and  black symbols are the measured data from the current study.  Continuous lines are the predicted responses. Note that for  OPRM1:c.118GA subjects, the predicted responses are equal to baseline (Effect(t) = baseline). M6G = morphine-6-glucuronide.