Fig. 3. Time to loss of righting reflex (  A ) and to recovery (  B ) in rats subjected to sleep deprivation or  ad libitum activity followed by intraperitoneal administration of ZM241385 or vehicle. The  graph depicts composite results from two separate experiments involving two doses of ZM241385. The  vehicle bar depicts the average of vehicle data from both high- and low-dose groups. High Dose =10 mg/kg intraperitoneal injection; Low Dose =5 mg/kg intraperitoneal injection. Values are expressed as mean ± SD. *  P < 0.05 by repeated-measures analysis of variance.