Fig. 4. Time to loss of righting reflex (  A ) and to recovery (  B ) in rats subjected to sleep deprivation or  ad libitum activity followed by coadministration of both ZM241385 and 8-cyclopentyltheophylline (8-CPT) (  vs. vehicle). Values are expressed as mean ± SD. *  P < 0.05 by repeated-measures analysis of variance.