Fig. 4. Simulated representation of the relation between time (minutes) from 12:00 h, propofol administration (0, 18, 30, and 36 mg/h), population predicted propofol concentration (dashed line ) and population predicted response COMFORT-Behavior score (COMFORT-B; A ) and Bispectral Index (BIS; B ) (solid lines ) in a 10-kg and a 5-kg infant.