Fig. 4. Simulation of plasma concentration (Cp) and adductor pollicis twitch tension (T1) after a bolus injection of vecuronium 0.1 mg/kg during isoflurane anesthesia in a 75-kg healthy volunteer. The figure shows the difference in effect of vecuronium when administered either at central body temperature 36.5°C or 34.4°C. The plasma concentration of vecuronium declines more slowly and the duration of vecuronium block is prolonged at 34.4°C. From Caldwell et al. 78 ; used with permission.