Fig. 1. Effects of selective cyclooxygenase 1 (COX-1) inhibition using SC560 after surgery in 4-week-old animals. The mechanical withdrawal threshold is presented over time. Baseline is before surgery and time 0 is 2 h after surgery and before injection of SC560. Intrathecal administration of 10 μg SC560 produced a time-dependent increase in withdrawal threshold ( P < 0.05) from baseline. At 1, 2, and 4 h, the intrathecal injection of 10 μg SC560 produced a higher withdrawal threshold than vehicle or systemic administration subcutaneously of the same 10-μg dose (* significantly different from vehicle control).