Fig. 4. Spontaneous Ca²⁺transients before, during, and after a 4-min exposure to 0.3 mm halothane plus 0.3 sevoflurane (  A ) and 0.1 mm halothane plus 0.5 mm sevoflurane (  C ). Mean data (± SEM) describing the number of spontaneous events per 30-s periods for 0.3 mm halothane plus 0.3 sevoflurane (  B , n = 15) and 0.1 mm halothane plus 0.5 mm sevoflurane (  D , n = 16). Control perfusate is shown as  gray bars , and anesthetic exposure is shown as  white bars . *  P < 0.05 to three or more of the four 30-s precontrol periods. #  P < 0.05 to two of the four precontrol periods and at least one postcontrol period.