American Society of Anesthesiologists

$Fig. 2. Sevoflurane, 330 μm, enhances currents activated by low (< 100 μm) concentrations of γ-aminobutyric acid (GABA). Whole cell responses to 0.3, 1, 3, 10, 30, 100, 300, and 1,000 μm GABA in the absence (first eight responses) and presence (last eight responses) of 330 μm sevoflurane. Whole cell recordings were made from HEK-293 cells voltage clamped at −60 mV expressing α1β2γ2sGABAAreceptor subunits. The filled bar above the current traces denotes the period of sevoflurane application, and the open bars denote the period of GABA application. The application of 330 μm sevoflurane shifted the EC50for GABA from 35.8 to 20.1 μm, a fractional shift of 0.56.$

Fig. 2. Sevoflurane, 330 μm, enhances currents activated by low (< 100 μm) concentrations of γ-aminobutyric acid (GABA). Whole cell responses to 0.3, 1, 3, 10, 30, 100, 300, and 1,000 μm GABA in the absence (first eight responses) and presence (last eight responses) of 330 μm sevoflurane. Whole cell recordings were made from HEK-293 cells voltage clamped at −60 mV expressing α¹β²γ^2sGABA^Areceptor subunits. The filled bar above the current traces denotes the period of sevoflurane application, and the open bars denote the period of GABA application. The application of 330 μm sevoflurane shifted the EC⁵⁰for GABA from 35.8 to 20.1 μm, a fractional shift of 0.56.

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