Fig. 3. Influences of acute late sepsis on the effects of rocuronium on the first endplate potential (EPP) amplitude (EPP¹amp;  A ), quantal content of the first EPP (  m ¹;  B ), and EPP^21–50amp/EPP¹amp (the quotient between averaged amplitude from the 21st to the 50th EPPs; EPP^21–50amp, and EPP¹amp), which indicates EPP run-down (  C ). Rocuronium dose-dependently decreased EPP¹amp (  A ),  m ¹(  B ), and EPP^21–50amp/EPP¹amp (  C ) in both the cecal ligation and puncture (CLP) group and the sham group. There was no significant difference in the rocuronium concentration–EPP¹amp curves (% of baseline) between the sham and CLP groups (  A ), but the rocuronium concentration–  m ¹curve (% of baseline) and rocuronium concentration–EPP^21–50amp/EPP¹amp curve in the CLP group significantly (  P < 0.01, each) shifted leftward and upward, respectively, compared with those in the sham group (  B and  C ). *  P < 0.01  versus sham; **  P < 0.05  versus sham; n = 30 at 0 μm rocuronium (baseline) and n = 6 at 1, 5, 10, 15, and 20 μm rocuronium, each.