![Fig. 2. Effect of volatile anesthetics on store-operated Ca2+entry (SOCE). Anesthetics did not significantly affect the intracellular calcium ([Ca2+]i) response to cyclopiazonic acid (CPA) ( A ), whereas 1 minimum alveolar concentration halothane, isoflurane, and sevoflurane all significantly inhibited SOCE. Sevoflurane was significantly less potent compared with halothane or isoflurane in inhibiting SOCE. With 1 μm acetylcholine (ACh) stimulation (during CPA exposure), SOCE was significantly enhanced ( B ). Halothane and isoflurane reversed such SOCE enhancement, but not sevoflurane. * Significant difference from control ( P < 0.05); § significant difference from halothane; # significant difference from acetylcholine. Values are mean ± SE.](https://asa2.silverchair-cdn.com/asa2/content_public/journal/anesthesiology/105/5/10.1097_00000542-200611000-00019/2/19ff2.png?Expires=1716634300&Signature=lN6fBBS11V1ygM-oS1-eZzZSYvRi0~J2d7Zwx0nZMHCszVy~~x6qsZ9-4NYmGOkN-UVcKb51q35NdeC87Vu1sSxh9V4shHbW0vkOaS~S571SV6aULoq9pnb8Y4Qecbz2Q4TPq-9ng7EEtOqa~woLGOd6sOmD1JM8Og-YZALz00exkeUM0Wf8IqwZOafEwHgXGgEI4CfjjvumDWN1pCxq9K01cTl4gnDS6~ejpnFn4DaHpOZXo5hWR8~yJGtKG3ZFru29IoJo-xQpxl7rokRcq0UovxuRIbmQ-2SEkN9p-iFXZk9ZMeuiVXLVO9a9kAp-8ourF0-epzcy2N8YoCiHyg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Fig. 2. Effect of volatile anesthetics on store-operated Ca2+entry (SOCE). Anesthetics did not significantly affect the intracellular calcium ([Ca2+]i) response to cyclopiazonic acid (CPA) ( A ), whereas 1 minimum alveolar concentration halothane, isoflurane, and sevoflurane all significantly inhibited SOCE. Sevoflurane was significantly less potent compared with halothane or isoflurane in inhibiting SOCE. With 1 μm acetylcholine (ACh) stimulation (during CPA exposure), SOCE was significantly enhanced ( B ). Halothane and isoflurane reversed such SOCE enhancement, but not sevoflurane. * Significant difference from control ( P < 0.05); § significant difference from halothane; # significant difference from acetylcholine. Values are mean ± SE.
