Fig. 2.  In vivo halothane challenge of wild-type (WT) and R163C heterozygous (Het) mice. (  A ) Hyperacute rigor mortis of a representative R163C Het mouse evidenced by contracture of skeletal muscles, notably the face, neck, and limbs. (  B ) Rectal temperature of R163C Het (▪) and control (•) mice after exposure to halothane. Data are pooled into 1-min bins and displayed with SDs. The period of exposure to halothane is denoted by the  bar above. (  C ) Rectal temperatures of WT and R163C Het mice before (  white bars ) and immediately after terminating the exposure to 42°C (  black bars ).