Fig. 2. Time course of hydroxyethyl starch (HES), carboxymethylated HES (CM-HES), or carboxymethyl starch (CMS) plasma concentration in g/l ( A ) and mm ( B ), weight-average molecular weight ( C ), and polydispersity ( D ). Results are shown as mean (SD). * Solution effect of CM-HES versus HES (Psol CM-HES) and CMS versus HES (Psol CMS) as determined by two-way analysis of variance. Numbers in parentheses indicate the number of animals in which HES plasma concentration and molecular weight were still detectable at the respective time points.