Fig. 1. Spared nerve injury (SNI) induces isolectin B4 (IB4) down-regulation, p38 activation, and CD11b (OX-42) up-regulation in the spinal cord dorsal horn 3 days after injury. ( A and B ) IB4 staining shows a reduction of the staining in the medial two thirds of the dorsal horn on the ipsilateral side after SNI. ( C – F ) Immunohistochemistry with phospho-p38 (p-p38) and OX-42 antibodies reveals an increase of p-p38–immunoreactive ( C and D ) and OX-42–immunoreactive ( E and F ) cells in the medial two thirds of the ipsilateral dorsal horn (L4) after SNI. White lines indicate the borders of the dorsal horn. White stars indicate the spinal area terminated by the intact sural nerve. Scale , 100 μm.