Fig. 6. Effects of repeated application of clonidine cream on the paw withdrawal latency (PWL;  A ) and the paw withdrawal threshold (PWT;  B ) in the postoperative pain model, and on PWL (  C ) and PWT (  D ) in the inflammatory pain model. PWL is shown as mean ± SEM, whereas PWT is shown as median and percentiles (n = 9 and 6 in each group of the postoperative and inflammatory pain models, respectively). *  P < 0.05  versus vehicle. ¶  P < 0.05  versus clonidine 3 μg. #  P < 0.05  versus clonidine 30 μg. CA = carrageenan injection; CLO = clonidine in cream.