American Society of Anesthesiologists

Fig. 3. Representative examples of the potentiation of EC20γ-aminobutyric acid responses by propofol (2 μm), etomidate (3 μm), and pregnenolone (50 nm). Whole cell current records were obtained from human embryonic kidney 293 cells expressing ( A ) wild-type α1β2γ2sand ( B ) mutant α1β2(Y444W)γ2sreceptors. Bars above the current traces indicate the duration of γ-aminobutyric acid ( filled bars ) and modulator ( open bars ) application. Calibration bars denote 10 s and 100 pA.

Fig. 3. Representative examples of the potentiation of EC²⁰γ-aminobutyric acid responses by propofol (2 μm), etomidate (3 μm), and pregnenolone (50 nm). Whole cell current records were obtained from human embryonic kidney 293 cells expressing ( A ) wild-type α¹β²γ^2sand ( B ) mutant α¹β²(Y444W)γ^2sreceptors. Bars above the current traces indicate the duration of γ-aminobutyric acid ( filled bars ) and modulator ( open bars ) application. Calibration bars denote 10 s and 100 pA.

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