Figure 1. (a) Measured (points), fitted (solid line), and predicted (dotted line) arterial serum concentrations of eltanolone emulsion together with the corresponding electroencephalographic median frequencies (b) for a representative volunteer (number 8). Eltanolone was administered by a computer-controlled infusion system supplied with pharmacokinetic data received after bolus injection and venous serum analyses. *RF 2,3