Fig. 6. Interaction between calcium-activated potassium channels (K^Ca) and voltage-gated potassium channels (Kv) 1.3 and 1.6. (  A –C ) Intrathecal pretreatment with 3 ng apamin, 1 ng charybdotoxin, or 10 ng margatoxin did not modify R-PIA–induced hypoalgesia, indicating that neither K^Canor Kv1.3 and Kv1.6 are involved in A¹adenosine receptor–mediated antinociception . *P < 0.05  versus 0 min by Friedman and Dunnett test.