Fig. 3. Effects of PD 098059 (PD, 50 μm), yohimbine (Yoh, 10−4m), and pertussis toxin (PT, 10−4m) on dexmedetomidine (Dex, 10−6m)–induced extracellular signal–regulated protein kinase 2 biphosphorylation (pERK2). Data (mean ± SD) are expressed as a fractional pERK2 phosphorylation on actin ratio increase from basal phosphorylation (control: 100%). Analysis of variance for pERK2 was F = 1,002, P < 0.0001. Post hoc analysis used Bonferroni correction. * P < 0.01, *** P < 0.0001 versus control. NS = not significant.
