Fig. 2. Accumulative postoperative chest tube blood loss according to plasminogen activator inhibitor type 1 genotypes, comparing placebo with tranexamic acid: 4G/G homozygotes (  blue box plots ), 4G/5G heterozygotes (  green box plots ), and 5G/G homozygotes (  red box plots ).  Horizontal line represents the median,  box encompasses the 25th–75th percentiles, and  whiskers encompass the minimum and maximum values. A corrected  P value less than 0.017 according to the Bonferroni test was significant.