Fig. 5. N-[3-(4′-Flurophenyl)-3-(4′-phenylphenoxy)propyl]sarcosine (NFPS) facilitates long-term potentiation in CA1 hippocampal synaptic transmission in slices prepared from Seltzer model mice. (  A ) Time course of long-term potentiation in slices prepared from sham-treated (  circles ) and Seltzer model (  triangles ) mice in the absence (  clear circles and  triangles ; vehicle) or presence (  solid circles and  triangles ) of NFPS (25 nm). High-frequency electrical stimulation was delivered at time 0. Each  point represents the mean ± SEM of eight separate experiments. (  B ) Long-term potentiation at 60 min after high-frequency electrical stimulation in slices from sham-treated and Seltzer model mice in the absence (  clear columns ; vehicle) or presence (  solid columns ) of NFPS (25 nm). (  C ) Representative averaged traces of two consecutive field excitatory postsynaptic potentials (fEPSPs) before (  broken line ) and 60 min after high-frequency electrical stimulation (  solid line ) during times on the time course graph were shown. The  asterisks and  daggers indicate data points for which a significant difference between the vehicle-treated Seltzer (  clear triangles in  A ) and vehicle-treated sham (  clear triangles in  A ) groups and between the vehicle-treated Seltzer (  clear triangles A ) and NFPS-treated Seltzer (  solid triangles in  A ) groups, respectively, was observed, as determined by two-tailed multiple  t test with Bonferroni correction after one-way analysis of variance (four comparisons in four groups, *  P < 0.05 and **  P < 0.01, †  P < 0.05 and ††  P <0.01). ns = not significant.